Abstract
We concisely review clinical, autopsy, experimental and molecular data of 2019 coronavirus disease (COVID-19). Angiotensin-converting enzyme 2 disruption and thromboinflammatory microangiopathy emerge as distinctive features. Briefly, entry of the virus into microvessels can profoundly disrupt the local renin-angiotensin system, cause endothelial injury, activate the complement cascade and induce powerful thromboinflammatory reactions, involving, in particular, von Willebrand factor, that, if widespread, may lead to microvascular plugging, ischemia and, ultimately, organ failure. We believe the current COVID-19 data consolidate a widely unrecognised paradigm of potentially fatal thromboinflammatory microvascular disease.
Keywords: 2019 coronavirus; Complement; Renin-angiotensin system; Thromboinflammatory microangiopathy; von Willebrand factor.
【저자키워드】 complement, von Willebrand factor., renin-angiotensin system, 2019 coronavirus, Thromboinflammatory microangiopathy, 【초록키워드】 COVID-19, Local, virus, Autopsy, Features, von Willebrand factor, 2019 coronavirus disease, endothelial injury, disease, Ischemia, Organ failure, Reactions, enzyme, cascade, molecular data, widespread, induce, activate, disrupt, 【제목키워드】 COVID-19, angiotensin-converting enzyme 2,