Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for the Coronavirus Disease-2019 (COVID-19) pandemic, has infected over 185 million individuals across 200 countries since December 2019 resulting in 4.0 million deaths. While COVID-19 is primarily associated with respiratory illnesses, an increasing number of clinical reports indicate that severely ill patients often develop thrombotic complications that are associated with increased mortality. As a consequence, treatment strategies that target COVID-associated thrombosis are of utmost clinical importance. An array of pharmacologically active compounds from natural products exhibit effects on blood coagulation pathways, and have generated interest for their potential therapeutic applications towards thrombotic diseases. In particular, a number of snake venom compounds exhibit high specificity on different blood coagulation factors and represent excellent tools that could be utilized to treat thrombosis. The aim of this review is to provide a brief summary of the current understanding of COVID-19 associated thrombosis, and highlight several snake venom compounds that could be utilized as antithrombotic agents to target this disease.
Keywords: Anticoagulant; Antiplatelet; Antithrombotic; COVID-19; Snake venom; Thrombosis.
【저자키워드】 COVID-19, thrombosis, Anticoagulant, Antithrombotic, antiplatelet, Snake venom, 【초록키워드】 SARS-CoV-2, coronavirus, pandemic, Diseases, thrombosis, Blood coagulation, coronavirus disease-2019, specificity, therapeutic, respiratory illnesses, disease, snake, Pathways, treatment strategy, deaths, acute respiratory syndrome, Factor, individual, Compound, thrombotic, increased mortality, treat, while, Effect, country, thrombotic complication, highlight, responsible, resulting, develop, severely ill patient, 【제목키워드】 Potential,