Background Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud’s phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies. Case presentation We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on chest imaging during the COVID-19 pandemic. High clinical suspicion for ASS with early appropriate therapy with corticosteroids and immunosuppressive agents led to marked clinical improvement. Conclusion High index of suspicion for ASS is mandated in patients with unexplained ILD. A comprehensive autoimmune work-up is important as an early treatment with corticosteroids with or without immunomodulators improves patient outcomes and survival in an otherwise poor prognostic disease.
【저자키워드】 Corticosteroids, Interstitial lung disease, Anti-synthetase syndrome, Autoimmune disease, 【초록키워드】 Corticosteroid, antibodies, Arthritis, Corticosteroids, therapy, COVID-19 pandemic, Lung disease, Interstitial lung disease, outcome, immunomodulator, immunomodulators, survival, Fever, early treatment, Patient, Clinical improvement, Autoimmune, prognostic, respiratory, disease, ILD, Immunosuppressive agents, Immune-mediated, association, chest imaging, myositis, skin changes, clinical suspicion, syndrome, respiratory symptom, suspicion, feature, IMPROVE, characterized, less, changes in, presenting, immunosuppressive agent, 【제목키워드】 Diagnosis, Case report, literature review,