Abstract
Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1β in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.
Keywords: CCL5/RANTES; COVID-19; CXCL9/MIG; SARS-CoV-2; T-cell activation.
【저자키워드】 COVID-19, SARS-CoV-2, CCL5/RANTES, CXCL9/MIG, T-cell activation., 【초록키워드】 SARS-CoV2, immune response, children, Th1, CD4, CD8, Adults, CXCL9, expression, IL-1β, IL-12, T-cell activation, immunological, feature, Cell, addition, activated, expressing, activated T cell, with COVID-19, 【제목키워드】 T-cell activation, characterized, children with COVID-19,