Abstract
Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3 + cells but rather CCR6 + , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
Keywords: CCL20; CCR6; COVID-19; T cells.
All Keywords
【저자키워드】 COVID-19, T cells, Ccr6, CCL20, 【초록키워드】 Immunity, T cells, Patient, expression, BALF, COVID-19 patients, Ligand, CD8 T cell, CXCR3, mechanically ventilated, Cell, 【제목키워드】 lung, CD8, T cell, enrichment, mechanically ventilated patient, with COVID-19,
【저자키워드】 COVID-19, T cells, Ccr6, CCL20, 【초록키워드】 Immunity, T cells, Patient, expression, BALF, COVID-19 patients, Ligand, CD8 T cell, CXCR3, mechanically ventilated, Cell, 【제목키워드】 lung, CD8, T cell, enrichment, mechanically ventilated patient, with COVID-19,
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기계적으로 환기되는 COVID-19 환자에서 높은 수준의 CXCR3 리간드에도 불구하고, BALF CD8 T 세포는 CXCR3+ 세포가 풍부하지 않고 오히려 CCR6+ , 아마도 BALF의 높은 CCL20 수준으로 인한 것일 수 있으며 PD-1 발현이 매우 높습니다. 기계적으로 환기되지만 병동이 아닌 환자의 Th-1 면역은 손상됩니다. .
{{ 키워드: }} CCL20; CCR6; 코로나바이러스감염증-19 : 코로나19; T 세포.