Background The Coronavirus disease 2019 (COVID-19) caused by the new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become a pandemic, affecting the therapeutic management for Multiple Sclerosis (MS). Any decision regarding the discontinuation of high-potency agents for moderate and highly active MS should be carefully evaluated, taking into account the potential risk of rebound of the disease. In particular, no data about clinical outcome of patients with MS receiving Natalizumab (NTZ) during active COVID-19 infection have been reported yet. Cases presentation We reported on 6 patients treated with NTZ for relapsing MS during active COVID-19 infection, who recovered without reporting any worsening or new symptoms. Most of the patients were asymptomatic, with the exception of one patient who had a slight worst COVID-19 clinical course. No patients received O2-therapy or required intensive care. No neurological complications were observed. Conclusions This paper reported the clinical outcome of patients with MS receiving NTZ during active COVID-19 infection. This case series suggests that treatment with NTZ during pandemic is relatively safe and might be continued in selected patients who are infected by COVID-19, thereby reducing the risk of MS disease rebound.
【저자키워드】 COVID-19, multiple sclerosis, SARS-CoV-2 active infection, Natalizumab, 【초록키워드】 Treatment, coronavirus disease, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, Coronavirus disease 2019, coronavirus, pandemic, intensive care, multiple sclerosis, risk, coronavirus 2, Symptoms, Clinical outcome, Natalizumab, Clinical course, Asymptomatic, COVID-19 infection, management, therapeutic, Patient, Neurological complications, respiratory, disease, moderate, Neurological complication, Safe, acute respiratory syndrome coronavirus, one patient, worsening, potential risk, rebound, Multiple, sclerosis, MOST, selected, caused, reported, the patient, the disease, evaluated, required, receiving, case sery, reducing, affecting, highly active, patients treated, relapsing, 【제목키워드】 SARS-CoV-2, Patient, administration, case sery,