Nanotechnology has gained much attention over the last decades, as it offers unique opportunities for the advancement of the next generation of sensing tools. Point-of-care (POC) devices for the selective detection of biomolecules using engineered nanoparticles have become a main research thrust in the diagnostic field. This review presents an overview on how the POC-associated nanotechnology, currently applied for the identification of nucleic acids, proteins and antibodies, might be further exploited for the detection of infectious pathogens: although still premature, future integrations of nanoparticles with biological markers that target specific microorganisms will enable timely therapeutic intervention against life-threatening infectious diseases. Highlights • Point-of-care (POC) devices are meant to improve the diagnosis of diseases. • POCs provide shorter assaying times, cost effectiveness, and simple procedures. • Nanotechnology-based POCs can be used for the detection of infectious pathogens.
【저자키워드】 Infectious diseases, HIV, Human immunodeficiency virus, Nanotechnology, Point-of-Care (POC), Pathogens, BSA, bovine serum albumin, ELISA, enzyme-linked immunosorbent assay, SARS, Severe acute respiratory syndrome, POC, point-of-care, RT-PCR, Real-time Polymerase Chain Reaction, diagnostic tools, SPR, surface plasmon resonance, HBV, hepatitis B virus, HEV, hepatitis E virus, LoD, limit of detection, HCV, hepatitis C virus, NAT, Nucleic acid test, MWCNTs, multi-walled carbon nanotubes, AuNPs, gold nanoparticles, ECM, electrochemical, QDs, quantum dots, RT-LAMP, reverse transcription loop mediated isothermal purification, NMOF, nano metal-organic framework, HbsAg, hepatitis B surface antigens, MNPs, Magnetic NanoParticles, MAP,