In light of the recent Coronavirus disease (COVID-19) pandemic, peripheral oxygen saturation (SpO 2 ) has shown to be amongst the vital signs most indicative of deterioration in persons with COVID-19. To allow for the continuous monitoring of SpO 2 , we attempted to demonstrate accurate SpO 2 estimation using our custom chest-based wearable patch biosensor, capable of measuring electrocardiogram (ECG) and photoplethysmogram (PPG) signals with high fidelity. Through a breath-hold protocol, we collected physiological data with a wide dynamic range of SpO 2 from 20 subjects. The ratio of ratios (R) used in pulse oximetry to estimate SpO 2 was robustly extracted from the red and infrared PPG signals during the breath-hold segments using novel feature extraction and PPG green -based outlier rejection algorithms. Through subject independent training, we achieved a low root-mean-square error (RMSE) of 2.64 ± 1.14% and a Pearson correlation coefficient (PCC) of 0.89. With subject-specific calibration, we further reduced the RMSE to 2.27 ± 0.76% and increased the PCC to 0.91. In addition, we showed that calibration is more efficiently accomplished by standardizing and focusing on the duration of breath-hold rather than the resulting range in SpO 2 . The accurate SpO 2 estimation provided by our custom biosensor and the algorithms provide research opportunities for a wide range of disease and wellness monitoring applications.
【저자키워드】 continuous monitoring, reflectance pulse oximetry, oxygen saturation, photoplethysmogram (PPG), respiratory monitoring, outlier rejection, 【초록키워드】 COVID-19, coronavirus disease, coronavirus, pandemic, protocol, pulse oximetry, oxygen, continuous monitoring, ECG, electrocardiogram, Deterioration, Algorithm, Research, vital signs, vital sign, disease, physiological, high fidelity, dynamic range, Algorithms, subject, peripheral oxygen saturation, calibration, Pearson correlation, photoplethysmogram, rejection, outlier, Pearson correlation coefficient, independent, shown, resulting, collected, addition, provided, reduced, subjects, PPG, PPG signal, with COVID-19, 【제목키워드】 oximetry, sternum, Continuous, Enabling, Reflectance,