Introduction Greece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95% CI 0.06–0.26). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in a nosocomial setting and assess potential risk factors. Methods HCWs from two hospitals participated in the study. Hospital-1 was a tertiary university affiliated center, involved in the care of COVID-19 patients while hospital-2 was a tertiary specialized cardiac surgery center not involved in the care of these patients. A validated, CE, rapid, IgM/IgG antibody point-of-care test was used. Comparative performance with a reference globally available assay was assessed. Results 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.26% (95% CI 0.43, 3.26) overall and 0.53% (95% CI 0.06, 2.78) and 2.70% (95% CI 0.57, 9.19) in hospital-1 and hospital-2, respectively although the study was underpowered to detect statistically significant differences. The overall, hospital-1, and hospital-2 seroprevalence was 10, 4 and 22 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. Conclusions These data have implications for the preparedness of a second wave of COVID-19 epidemic, given the low burden of SARS-CoV-2 infection rate, in concordance with national projections.
【초록키워드】 COVID-19, SARS-CoV-2, Personal protective equipment, Health care, antibody, SARS-COV-2 infection, hospital, health care workers, Seroprevalence, nosocomial, Infection, risk, anti-SARS-CoV-2, hospitals, Spread, Prevalence, point-of-care, IgG antibody, Concordance, HCWs, IgM/IgG, attack rate, Factors, Greece, second wave, General population, Care, patients, COVID-19 patients, COVID-19 epidemic, COVID-19 patient, HCW, response rate, Comparative, 95% CI, These data, individual, potential risk, National, cumulative, implication, country, Result, was used, detect, involved, statistically significant, participated, 【제목키워드】 COVID-19, SARS-CoV-2, Health care, Health care worker, country,