Background Among the challenges for personalizing the management of mechanically ventilated patients with coronavirus disease (COVID-19)-associated acute respiratory distress syndrome (ARDS) are the effects of different positive end-expiratory pressure (PEEP) levels and body positions in regional lung mechanics. Right-left lung aeration asymmetry and poorly recruitable lungs with increased recruitability with alternating body position between supine and prone have been reported. However, real-time effects of changing body position and PEEP on regional overdistension and collapse, in individual patients, remain largely unknown and not timely monitored. The aim of this study was to individualize PEEP and body positioning in order to reduce the mechanisms of ventilator-induced lung injury: collapse and overdistension. Methods We here report a series of five consecutive mechanically ventilated patients with COVID-19-associated ARDS in which sixteen decremental PEEP titrations were performed in the first days of mechanical ventilation (8 titration pairs: supine position immediately followed by 30° targeted lateral position). The choice of lateral tilt was based on X-Ray. This targeted lateral position strategy was defined by selecting the less aerated lung to be positioned up and the more aerated lung to be positioned down. For each PEEP level, global and regional collapse and overdistension maps and percentages were measured by electrical impedance tomography. Additionally, we present the incidence of lateral asymmetry in a cohort of forty-four patients. Results The targeted lateral position strategy resulted in significantly smaller amounts of overdistension and collapse when compared with the supine one: less collapse along the PEEP titration was found within the left lung in targeted lateral ( P = 0.014); and less overdistension along the PEEP titration was found within the right lung in targeted lateral ( P = 0.005). Regarding collapse within the right lung and overdistension within the left lung : no differences were found for position. In the cohort of forty-four patients, ventilation inequality of > 65/35% was observed in 15% of cases. Conclusions Targeted lateral positioning with bedside personalized PEEP provided a selective attenuation of overdistension and collapse in mechanically ventilated patients with COVID-19-associated ARDS and right-left lung aeration/ventilation asymmetry. Trial registration Trial registration number: NCT04460859
【저자키워드】 coronavirus disease, acute respiratory distress syndrome, mechanical ventilation, body position, Ventilator-induced lung injury, Positive end-expiratory pressure, 【초록키워드】 ARDS, Ventilation, lung, Electrical impedance tomography, Cohort, management, incidence, patients, mechanism, acute respiratory distress, Supine position, PEEP, no difference, syndrome, selective, Effect, Recruitability, FIVE, lung mechanics, COVID-19-associated ARDS, Result, defined, performed, significantly, reported, provided, less, reduce, were measured, mechanically ventilated patient, percentage, positioned, 【제목키워드】 lung collapse, decrease, COVID-19-associated ARDS,