Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-021-05855-9.
【저자키워드】 COVID-19, Computed tomography, clinical laboratory, 【초록키워드】 Neutrophils, SARS-CoV-2, Prognosis, cross-sectional, SARS-COV-2 infection, COVID-19 pandemic, lung involvement, LDH, C-reactive protein, CRP, procalcitonin, oxygen, Italy, pulmonary, Laboratory testing, Lymphocyte count, ground-glass opacity, oxygen saturation, Cohort, COVID-19 pathogenesis, outbreak, Gas exchange, Patient, Platelet, Clinical management, AST, consolidation, patients, COVID-19 patients, association, leukocytes, ALT, Inflammatory response, creatinine, chest CT scan, lung lesion, lesion, supplementary material, laboratory data, worsening, extension, positive, end-organ damage, decrease, Result, highest, evaluate, raised, reduced, determine, increase in, presenting, Total, consecutive patient, CT finding, parenchymal, 【제목키워드】 disease severity, Cohort, Chest CT, association, COVID-19 patient, laboratory data, Italian, explain,