Background While our knowledge about COVID-19 in adults has rapidly increased, data on the course of disease and outcome in children with different comorbidities is still limited. Methods Prospective, observational study at a tertiary care children’s hospital in southern Germany. Clinical and virology data from all paediatric patients admitted with SARS-CoV-2 infection at our hospital were prospectively assessed. Results Between March and November 2020, 14 patients were admitted with COVID-19. One patient was admitted a second time with COVID-19 6 months after initial disease. Among seven patients with severe underlying comorbidities, three developed multisystem inflammatory syndrome (MIS-C), two were admitted to the paediatric intensive care unit. One patient needed invasive ventilation. Another patient died shortly after discharge of COVID-19-related complications. Conclusions While COVID-19 generally causes mild disease in children, severe respiratory illness and MIS-C occur, in some cases with fatal outcome. Children with underlying diseases might be at special risk for severe disease.
【저자키워드】 COVID-19, children, Comorbidity, SARS CoV-2 infection, Inpatients, 【초록키워드】 intensive care, knowledge, SARS-COV-2 infection, hospital, Comorbidities, risk, outcome, underlying disease, invasive ventilation, discharge, MIS-C, Germany, clinical, Prospective, Patient, Mild, severe respiratory illness, disease, Care, Inflammatory, severe disease, one patient, syndrome, COVID-19-related complications, while, Seven, initial, Course, Result, died, occur, cause, paediatric patient, with COVID-19, 【제목키워드】 hospital, Germany, Care, case sery, with COVID-19,