SARS-CoV-2 betacoronavirus is responsible for the Corona Virus Disease 2019 (COVID-19) which has relevant pathogenic implications for the cardiovascular system. Incidence and severity of COVID-19 are higher in the elderly population (65 years and older). This may be due to higher frequency of comorbidities, but increased frailty and immunosenescence linked with aging may also contribute. Moreover, in elderly individuals, SARS-CoV-2 may adopt different molecular strategies to strongly impact on cardiac aging that culminate in exacerbating a pro-inflammatory state (cytokine storm activation), which, in turn, may lead to pulmonary vascular endothelialitis, microangiopathy, diffuse thrombosis, myocarditis, heart failure, cardiac arrhythmias, and acute coronary syndromes. All these events are particularly relevant in elderly patients, and deserve targeted cardiovascular treatments and specific management of repurposed drugs against COVID-19. We discuss current evidence about the cardiovascular involvement during COVID-19, and elaborate on clinical implications in elderly patients. Highlights • SARS-CoV-2 infection has relevant pathogenic implications for the heart, mainly in elderly patients. • Common cardiometabolic comorbidities and aging strongly contribute to higher frequency and severity of disease in elderly. • SARS-CoV-2 may directly and indirectly damage the heart leading to multi-organ failure and death. • Network-oriented analysis are providing novel insight about SARS-CoV-2 pathogenic mechanisms and putative drug targets.
【저자키워드】 COVID-19, Inflammation, ACE2, troponin, Cytokine release syndrome, heart failure, myocarditis, Vasculitis, cardiovascular drugs, SARS-CoV 2, 【초록키워드】 Treatment, SARS-CoV-2, Cytokine storm, thrombosis, SARS-COV-2 infection, Comorbidities, frailty, Comorbidity, cardiovascular system, elderly patients, Betacoronavirus, Repurposed drug, Corona, severity of COVID-19, management, death, targets, Severity of disease, molecular, pathogenic mechanism, acute coronary syndromes, cardiometabolic, Evidence, Frequency, Analysis, cardiac arrhythmias, Older, Activation, Vascular, multi-organ failure, pathogenic, pro-inflammatory state, implication, event, common, responsible, contribute, individuals, turn, clinical implication, exacerbating, 【제목키워드】 elderly patients, cardiovascular, clinical implication,