Abstract Background Since 2020, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become prevalent worldwide. In severe cases, the case fatality rate is high, and vaccine prevention is important. This study evaluated the safety of receiving SARS‐CoV‐2 vaccine in patients with advanced lung cancer receiving anticancer therapy. Methods We prospectively enrolled patients receiving anticancer drugs for advanced lung cancer who planned to receive SARS‐CoV‐2 vaccination. Early adverse events within 7 days of vaccine injection were evaluated using patient‐reported surveys. The chi‐square test and multivariate logistic regression analyses were used. Results Among 120 patients receiving lung cancer treatment, 73 were men; the mean age of the patients was 73.5 years. The treatments received for lung cancer at the time of the first vaccine injection were chemotherapy, ICIs, combined chemotherapy and ICIs, and targeted therapies, including tyrosine kinase inhibitors, in 30, 28, 17, and 45 patients, respectively. All patients received SARS‐CoV‐2 messenger RNA (mRNA) vaccine. After the second mRNA vaccine dose, 15.4% of patients had fever of 38°C (95% confidence interval: 9.34%–23.2%); this rate was slightly higher than that for healthy participants at the time of the BNT162b2 trial. Patients treated with cytotoxic anticancer drugs tended to have high fever. In the multivariate analyses, male sex was associated with higher fever frequencies. However, there were no serious early adverse events due to vaccination. Conclusions Anti‐SARS‐CoV‐2 mRNA vaccination tends to be safe, but fever following vaccination tends to be more common among patients undergoing lung cancer treatment than among healthy individuals. Anti‐SARS‐CoV‐2 messenger RNA vaccination itself tends to be safe. Vaccine‐related AEs tend to increase in lung cancer patients with chemotherapy. Serious adverse events are comparable to those in healthy individuals.
【저자키워드】 COVID‐19, Vaccine, SARS‐CoV‐2, lung cancer, anticancer drugs, 【초록키워드】 Treatment, mRNA vaccination, coronavirus, vaccination, therapy, Trial, mRNA vaccine, SARS‐CoV‐2, Chemotherapy, BNT162b2, mRNA, Fever, adverse event, Patient, severe cases, age, patients, Therapies, Analysis, dose, Male sex, Safe, tyrosine kinase inhibitors, Messenger RNA, acute respiratory syndrome, frequencies, healthy individuals, multivariate logistic regression, Fatality rate, participant, multivariate analyses, anticancer, prevalent, Result, enrolled, healthy, the patient, evaluated, receiving, treated, were used, increase in, comparable, the mean, receive, anticancer drug, in healthy individuals, lung cancer patient, vaccine injection, 【제목키워드】 coronavirus, RNA, Patient, multicenter, acute respiratory syndrome, anticancer, treated,