The incidence of pulmonary embolism (PE) is high during severe Coronavirus Disease 2019 (COVID-19). We aimed to identify predictive and prognostic factors of PE in non-ICU hospitalized COVID-19 patients. In the retrospective multicenter observational CLOTVID cohort, we enrolled patients with confirmed RT-PCR COVID-19 who were hospitalized in a medicine ward and also underwent a CT pulmonary angiography for a PE suspicion. Baseline data, laboratory biomarkers, treatments, and outcomes were collected. Predictive and prognostics factors of PE were identified by using logistic multivariate and by Cox regression models, respectively. A total of 174 patients were enrolled, among whom 86 (median [IQR] age of 66 years [55–77]) had post-admission PE suspicion, with 30/86 (34.9%) PE being confirmed. PE occurrence was independently associated with the lack of long-term anticoagulation or thromboprophylaxis (OR [95%CI], 72.3 [3.6–4384.8]) D-dimers ≥ 2000 ng/mL (26.3 [4.1–537.8]) and neutrophils ≥ 7.0 G/L (5.8 [1.4–29.5]). The presence of these two biomarkers was associated with a higher risk of PE ( p = 0.0002) and death or ICU transfer (HR [95%CI], 12.9 [2.5–67.8], p < 0.01). In hospitalized non-ICU severe COVID-19 patients with clinical PE suspicion, the lack of anticoagulation, D-dimers ≥ 2000 ng/mL, neutrophils ≥ 7.0 G/L, and these two biomarkers combined might be useful predictive markers of PE and prognosis, respectively.
【저자키워드】 COVID-19, Mortality, anticoagulation, neutrophil, D-dimer, Pulmonary embolism, prognostic, predictive factor, ICU transfer, 【초록키워드】 Biomarker, Hospitalized, Prognosis, outcome, RT-PCR, ICU, Cohort, Patient, death, age, laboratory biomarkers, incidence, multicenter, marker, Thromboprophylaxis, retrospective, Prognostic factor, Predictive, pulmonary angiography, Logistic, Factor, hospitalized COVID-19 patients, higher risk, non-ICU, transfer, baseline data, Cox regression models, Occurrence, enrolled, identify, lack, collected, median, severe COVID-19 patient, 【제목키워드】 pulmonary, Embolism, Factor, count, Level,