The essential trace element selenium (Se) is of central importance for human health and particularly for a regular functioning of the immune system. In the context of the current pandemic, Se deficiency in patients with COVID-19 correlated with disease severity and mortality risk. Selenium has been reported to be associated with the immune response following vaccination, but it is unknown whether this also applies to SARS-CoV-2 vaccines. In this observational study, adult health care workers (n = 126) who received two consecutive anti-SARS-CoV-2 vaccinations by BNT162b2 were followed for up to 24 weeks, with blood samples collected at the first and second dose and at three and 21 weeks after the second dose. Serum SARS-CoV-2 IgG titres, neutralising antibody potency, total Se and selenoprotein P concentrations, and glutathione peroxidase 3 activity were quantified. All three biomarkers of Se status were significantly correlated at all the time points, and participants who reported supplemental Se intake displayed higher Se concentrations. SARS-CoV-2 IgG titres and neutralising potency were highest three weeks after the second dose and decreased towards the last sampling point. The humoral immune response was not related to any of the three Se status biomarkers. Supplemental Se intake had no effect at any time point on the vaccination response as measured by serum SARS-CoV-2 IgG levels or neutralising potency. Overall, no association was found between Se status or supplemental Se intake and humoral immune response to COVID-19 mRNA vaccination. Graphical abstract Image 1 Highlights • Humoral SARS-CoV-2 vaccination response in healthy adults was unrelated to baseline Se status or supplemental Se intake. • Vaccine-induced neutralising activity correlated with SARS-CoV-2 IgG concentration, but not with Se status. • Rise and decline of the vaccination-induced SARS-CoV-2 IgG was Se status-independent during 24 weeks after first dose.
【저자키워드】 SARS-CoV-2, Vaccine, antibody, cohort study, Glutathione peroxidase, 【초록키워드】 immune response, vaccination, pandemic, Biomarker, Biomarkers, disease severity, SARS-CoV-2 vaccines, immune system, BNT162b2, serum, Health, neutralising antibody, Health care worker, Selenium, humoral immune response, Selenoprotein P, SARS-CoV-2 IgG, SARS-CoV-2 vaccination, anti-SARS-CoV-2 vaccination, Neutralising activity, association, mortality risk, Concentration, Image, peroxidase, COVID-19 mRNA Vaccination, Abstract, titres, second dose, first dose, blood sample, participant, titre, concentrations, neutralising, highest, collected, significantly, healthy, reported, correlated, had no, quantified, baseline, patients with COVID-19, Se deficiency, 【제목키워드】 immune response, COVID-19 mRNA Vaccination,