Background Sero-prevalence studies quantify the proportion of a population that has antibodies against SARS-CoV-2, and can be used to identify the extent of the COVID-19 pandemic at a population level. The aim of the study was to assess the sero-prevalence of SARS-CoV-2 antibodies in the workforce at three workplaces: a food factory, non-food factory and call-centre. Methods Nine hundred ninety-three participants were recruited from three workplaces in South Wales. Participants completed a questionnaire and had a lateral flow point-of-care SARS-CoV-2 antibody test administered by a healthcare professional. The data were analysed using multivariable logistic regression, both using complete records only and following multiple imputation . Results The sero-prevalence of SARS-CoV-2 antibodies ranged from 4% ( n = 17/402) in the non-food factory to 10% ( n = 28/281) in the food factory (OR 2.93; 95% CI 1.26 to 6.81). After taking account of confounding factors evidence of a difference remained (cOR comparing food factory to call centre (2.93; 95% CI 1.26 to 6.81) and non-food factory (3.99; 95% CI 1.97 to 8.08) respectively). The SARS-CoV-2 antibody prevalence also varied between roles within workplaces. People working in office based roles had a 2.23 times greater conditional odds (95% CI 1.02 to 4.87) of being positive for SARS-CoV-2 antibodies than those working on the factory floor. Conclusion The sero-prevalence of SARS-CoV-2 antibodies varied by workplace and work role. Whilst it is not possible to state whether these differences are due to COVID-19 transmission within the workplaces, it highlights the importance of considering COVID-19 transmission in a range of workplaces and work roles.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, Sero-prevalence, Sero-epidemiology, Workplace, 【초록키워드】 COVID-19 pandemic, Prevalence, lateral flow, point-of-care, SARS-CoV-2 antibodies, SARS-CoV-2 antibody, SARS-CoV-2 antibody test, Antibody test, questionnaire, Healthcare professional, Evidence, COVID-19 transmission, evidence of, multiple imputation, work role, call centre, 95% CI, multivariable logistic regression, population level, participant, South, positive, Administered, Complete, highlight, Result, greater, identify, proportion, recruited, remained, analysed, can be used, ranged, 1.26, confounding factor, 【제목키워드】 South,