Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered coronavirus, SARS-CoV-2. Increased severity of COVID-19 has been observed in patients with diabetes mellitus (DM). This study aimed to identify common transcriptional signatures, regulators and pathways between COVID-19 and DM. We have integrated human whole-genome transcriptomic datasets from COVID-19 and DM, followed by functional assessment with gene ontology (GO) and pathway analyses. In peripheral blood mononuclear cells (PBMCs), among the upregulated differentially expressed genes (DEGs), 32 were found to be commonly modulated in COVID-19 and type 2 diabetes (T2D), while 10 DEGs were commonly downregulated. As regards type 1 diabetes (T1D), 21 DEGs were commonly upregulated, and 29 DEGs were commonly downregulated in COVID-19 and T1D. Moreover, 35 DEGs were commonly upregulated in SARS-CoV-2 infected pancreas organoids and T2D islets, while 14 were commonly downregulated. Several GO terms were found in common between COVID-19 and DM. Prediction of the putative transcription factors involved in the upregulation of genes in COVID-19 and DM identified RELA to be implicated in both PBMCs and pancreas. Here, for the first time, we have characterized the biological processes and pathways commonly dysregulated in COVID-19 and DM, which could be in the next future used for the design of personalized treatment of COVID-19 patients suffering from DM as comorbidity.
【저자키워드】 COVID-19, Diabetes Mellitus, blood gene expression, transcriptional signatures, molecular pathways, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, Type 1 diabetes, Coronavirus disease 2019, coronavirus, Diabetes Mellitus, Comorbidity, prediction, Gene ontology, Infectious disease, diabetes, Peripheral blood, type 2 diabetes, severity of COVID-19, Ontology, Peripheral blood mononuclear cells, pathway, PBMC, dataset, differentially expressed gene, pancreas, PBMCs, Pathways, Organoid, COVID-19 patient, islets, T2D, Functional assessment, transcription factor, mononuclear cells, transcription factors, followed by, mononuclear cell, biological processes, upregulation, DEGs, RELA, whole-genome, transcriptomic, transcriptional, identify, caused, involved, characterized, functional, upregulated, dysregulated, analyses, implicated, Increased, downregulated, T1D, diabete, biological processe, modulated, GO term, pancrea, patients with diabete, type 2 diabete, 【제목키워드】 Differential gene expression, Analysis,