Since the outbreak of COVID-19 in China at the end of 2019, the world has experienced a large-scale epidemic caused by the SARS-CoV-2. The epidemiological and clinical course of COVID-19 patients has been reported, but there have been few analyses about the characteristics, predictive risk factors, and outcomes of critical patients. In this single-center retrospective case–control study, 90 adult inpatients hospitalized at Tongji Hospital (Wuhan, China) were included. Demographic, clinical, laboratory tests, and treatment data were obtained and compared between critical and non-critical patients. We found that compared with non-critical patients, the critical patients had higher SOFA score and qSOFA scores. Critical patients had lower lymphocyte and platelet count, elevated D-dimer, decreased fibrinogen, and elevated high-sensitivity C-reactive protein (hsCRP), and interleukin-6(IL-6). More critical patients received treatment including antibiotics, anticoagulation, corticosteroid, and oxygen therapy than non-critical ones. Multivariable regression showed higher qSOFA score and elevation of IL-6 were related to critical patients. Antibiotic usage and anticoagulation were associated with decreased in-hospital mortality. And critical grouping contributed greatly to in-hospital death. Critical COVID-19 patients have a more severe clinical course. qSOFA score and elevation of IL-6 are risk factors for critical condition. Non-critical grouping, positive antibiotic application, and anticoagulation may be beneficial for patient survival.
【저자키워드】 Infectious diseases, Respiratory tract diseases, 【초록키워드】 Corticosteroid, COVID-19, Treatment, Risk factors, Hospitalized, anticoagulation, IL-6, D-dimer, Laboratory tests, Antibiotics, outcome, risk factor, China, lymphocyte, Clinical course, hsCRP, Epidemic, Characteristics, outbreak, Patient, Oxygen therapy, Platelet, fibrinogen, epidemiological, demographic, Critical, patients, in-hospital mortality, antibiotic, retrospective, COVID-19 patient, Predictive, SOFA score, In-hospital death, qSOFA, Inpatient, High-sensitivity C-reactive protein, patient survival, Multivariable regression, single-center, critical condition, Tongji Hospital, positive, critical patient, Wuhan, China, caused, reported, elevated, analysis, contributed, the SARS-CoV-2, 【제목키워드】 survival, Characteristics, clinical, Wuhan, Critical, retrospective, Analysis, case control study, single-center, patients with COVID-19,