Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
【저자키워드】 Risk factors, Dyslipidaemias, 【초록키워드】 COVID-19, Evolution, Inflammation, severe COVID-19, Prognosis, Hospitalization, cross-sectional, SARS-COV-2 infection, Infection, ferritin, outcome, serum, COVID-19 infection, Triglyceride, Mild, plasma, cholesterol, predictor, predict, association, HDL, marker, LDL, COVID-19 prognosis, D-dimer level, Concentration, Lipid, triglycerides, infection process, CRP levels, clinical evolution, dyslipidaemia, Course, the disease, evaluated, analysed, hospitalized patient, correlated, patients with COVID-19, the SARS-CoV-2, with COVID-19, 【제목키워드】 COVID-19 severity, Triglyceride, predict, HDL,