Several studies have reported clinical manifestations of the new coronavirus disease. However, few studies have systematically evaluated the neuropsychiatric complications of COVID-19. We reviewed the medical records of 201 patients with confirmed COVID-19 (52 outpatients and 149 inpatients) that were treated in a large referral center in Tehran, Iran from March 2019 to May 2020. We used clustering approach to categorize clinical symptoms. One hundred and fifty-one patients showed at least one neuropsychiatric symptom. Limb force reductions, headache followed by anosmia, hypogeusia were among the most common neuropsychiatric symptoms in COVID-19 patients. Hierarchical clustering analysis showed that neuropsychiatric symptoms group together in three distinct groups: anosmia and hypogeusia; dizziness, headache, and limb force reduction; photophobia, mental state change, hallucination, vision and speech problem, seizure, stroke, and balance disturbance. Three non-neuropsychiatric cluster of symptoms included diarrhea and nausea; cough and dyspnea; and fever and weakness. Neuropsychiatric presentations are very prevalent and heterogeneous in patients with coronavirus 2 infection and these heterogeneous presentations may be originating from different underlying mechanisms. Anosmia and hypogeusia seem to be distinct from more general constitutional-like and more specific neuropsychiatric symptoms. Skeletal muscular manifestations might be a constitutional or a neuropsychiatric symptom.
【저자키워드】 Medical research, Health care, Diseases, Psychology, 【초록키워드】 COVID-19, coronavirus, Clinical symptoms, stroke, Infection, Symptom, cough, headache, diarrhea, Symptoms, Anosmia, Iran, Fever, Patient, Clustering, Cluster, Neuropsychiatric, mechanisms, disease, COVID-19 patients, New coronavirus, Outpatient, Seizure, manifestation, Dizziness, medical record, clinical manifestation, Inpatients, Hypogeusia, Hallucination, weakness, Hierarchical clustering analysis, heterogeneous, Tehran, complications of COVID-19, Mental, approach, prevalent, limb, reported, evaluated, treated, muscular, 【제목키워드】 COVID-19, Symptom, manifestation, category,