Absence of nucleotide‐binding oligomerization domain‐containing protein 2 variants in patients with leprosy and tuberculosis

결핵 및 결핵 환자에서 뉴클레오티드 결합 올리고머리제이션 도메인을 포함한 단백질 2 변이의 부재

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Journal: International Journal of Immunogenetics
[저자] V. Singh, R. Gaur, M. Mittal, S. K. Biswas, R. Das, B. K. Girdhar, B. Bajaj, V. M. Katoch, A. Kumar, K. K. Mohanty
[Category] 한센병,
Pubmed URL    DOI URL    [DOI] 10.1111/j.1744-313X.2012.01085.x    
[Article Type] journal-article
[Source] pubmed

Crohn’s disease-associated NOD 2 variants (Arg702Trp and 3020insC) were found to be monomorphic (wild), and 7 subjects were heterozygous for Gly908Arg SNP in 263 patients with tuberculosis, 260 patients with leprosy and 270 healthy controls residing in northern Indian states. This is the first report to suggest the minimal role of these variants in susceptibility/resistance to TB and leprosy in this population.

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