Vaccination with inactivated SARS-CoV-2 virus produces suboptimal immune responses among kidney transplant (KT), peritoneal dialyzed (PD), and hemodialyzed (HD) patients. Participants were vaccinated with two-dose inactivated SARS-CoV-2 vaccine (V2) and a third dose of ChAdOx1 nCoV-19 vaccine (V3) at 1–2 months after V2. We enrolled 106 participants: 31 KT, 28 PD, and 31 HD patients and 16 controls. Among KT, PD, and HD groups, median (IQR) of anti-receptor binding domain antibody levels were 1.0 (0.4–26.8), 1092.5 (606.9–1927.2), and 1740.9 (1106–3762.3) BAU/mL, and percent neutralization was 0.9 (0–9.9), 98.8 (95.9–99.5), and 99.4 (98.8–99.7), respectively, at two weeks after V3. Both parameters were significantly increased from V2 across all groups ( p < 0.05). Seroconversion and neutralization positivity rates in PD, HD, and control groups were 100% but were impaired in KT patients (39% and 16%, respectively). S1-specific T-cell counts were increased in PD and HD groups ( p < 0.05) but not in KT patients. The positive S1-specific T-cell responder rate was > 90% in PD, HD, and control groups, which was higher than that in KT recipients (74%, p < 0.05). The heterologous inactivated virus/ChAdOx1 nCoV-19 vaccination strategy elicited greater immunogenicity among dialysis patients; however, inadequate responses remained among KT recipients (TCTR20210226002).
【저자키워드】 Infectious diseases, Nephrology, 【초록키워드】 immune response, antibody, neutralization, SARS-CoV-2 virus, SARS-CoV-2 vaccine, dialysis, response, Patient, T-cell, group, patients, Heterologous, kidney transplant, inactivated, ChAdOx1 nCoV-19 vaccine, dose, Vaccination strategy, control group, HD group, control groups, participant, binding domain, positive, recipient, parameter, controls, significantly increased, greater, enrolled, remained, median, groups, elicited, IQR, 【제목키워드】 immunogenicity, dialysis, Patient, SARS-CoV-2 vaccination, inactivated, ChAdOx1 nCoV-19 vaccine, kidney transplant recipient,