We conducted a retrospective analysis of the clinical characteristics and dynamic variations of immune indexes in nine COVID-19 patients in Zigong, China. We used flow cytometry and enzyme-linked immunosorbent assays to measure the absolute levels of CD4 and CD8 lymphocytes and SARS-CoV-2 antibodies, respectively. We found that CRP, LDH, HBDH, CD4/CD8 and IgE levels were increased in 6/9 patients, while PA and the absolute numbers of CD4 and CD8 lymphocytes decreased in 7/9 patients. From disease onset through 63 days of follow-up, SARS-CoV-2 IgG levels were consistently higher than those of SARS-CoV-2 IgM, reaching peaks on days 28 and 13, respectively. IgM levels decreased to normal 35 days after disease onset, while IgG levels remained elevated through day 63. IgE levels varied similarly to SARS-CoV-2 IgM. Our results suggest that SARS-CoV-2 may elicit allergic immune responses in patients and that the levels of CRP, PA, LDH, and HBDH, as well as the absolute numbers of CD4 and CD8 lymphocytes could be used as early diagnostic markers of SARS-CoV-2 infection. Lastly, the dynamic variation of SARS-CoV-2 antibodies could guide the timing of blood collection for plasma exchange.
【저자키워드】 COVID-19, dynamic monitoring, early diagnostic markers, IgE, SARS-CoV-2 antibodies, 【초록키워드】 SARS-CoV-2, IgM, immune response, Lymphocytes, Clinical characteristics, SARS-COV-2 infection, Variation, diagnostic, LDH, CRP, CD4, flow cytometry, immune, China, enzyme-linked immunosorbent assay, SARS-CoV-2 antibodies, SARS-CoV-2 antibody, enzyme-linked immunosorbent assays, immune responses, plasma exchange, Patient, Retrospective analysis, plasma, Follow-up, patients, SARS-CoV-2 IgG, SARS-CoV-2 IgM, marker, COVID-19 patient, disease onset, absolute levels, CD8 lymphocyte, enzyme, IgG levels, allergic, blood collection, CD4/CD8, CD8 lymphocytes, remained, elevated, conducted, nine, elicit, IgG level, the timing, 【제목키워드】 immune function, COVID-19 patient, dynamic,