Several drug candidates have been proposed and tested as the latest clinical treatment for coronavirus pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are under trials for the treatment of this disease. The hyperpolarization technique has the ability to further provide a better understanding of the roles of these drugs at the molecular scale and in different applications in the field of nuclear magnetic resonance/magnetic resonance imaging. This technique may provide new opportunities in diagnosis and research of COVID-19. Signal amplification by reversible exchange-based hyperpolarization studies on large-sized drug candidates were carried out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented long-distance polarization transfer by para -hydrogen. We also found that the optimal magnetic field for the maximum polarization transfer yield was dependent on the molecular structure. We can expect further research on the hyperpolarization of other important large molecules, isotope labeling, as well as polarization transfer on nuclei with a long spin relaxation time. A clinical perspective of these features on drug molecules can broaden the application of hyperpolarization techniques for therapeutic studies.
【저자키워드】 Analytical chemistry, NMR spectroscopy, Medical and clinical diagnostics, 【초록키워드】 COVID-19, Treatment, Trial, Hydroxychloroquine, Coronavirus pneumonia, Diagnosis, Favipiravir, drug, amplification, therapeutic, Research, molecular, disease, structures, Clinical treatment, Perspective, signal, transfer, drug candidate, nuclear, labeling, feature, nuclei, tested, carried, dependent on, 【제목키워드】 COVID-19, antiviral drug, amplification, signal, candidate,