The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.
【저자키워드】 Risk factors, Microbiology, 【초록키워드】 COVID-19, Prognosis, IL-6, hospital, Comorbidities, hypertension, ICU, lymphopenia, kidney, survival, lymphocytopenia, Dyspnea, Patient, predictor, disease, liver, COVID-19 patients, Dyspnoea, COVID-19 patient, regression analysis, Serum ferritin, Clinical data, advanced age, transfer, organ damage, Kaplan–Meier analysis, multivariable, performed, develop, evaluate, the patient, investigated, elevated, suggested, diabete, had more, 【제목키워드】 disease, Factor, potential risk, patients with COVID-19,