[[[ Introduction: ]]] Poliomyelitis causes selective destruction of anterior horn cells and usually has a stable disease course post-infection. We assessed the excitability characteristics in patients with a stable course after past poliomyelitis and compared them with changes described in amyotrophic lateral sclerosis (ALS). [[[ Methods: ]]] The excitability characteristics of motor and sensory nerves were studied in 10 subjects with stable past poliomyelitis. [[[ Results: ]]] Motor rheobase was increased, but there were no significant changes in strength-duration properties or depolarizing threshold electrotonus, as have been seen in previous studies of ALS. [[[ Conclusions: ]]] There is minimal change in axonal excitability properties in patients with stable past poliomyelitis. The results may signify sufficient compensation in the stable state of the disease. Increased subexcitability in 1 subject with demonstrable hyperexcitability may represent compensation for increased ectopic activity rather than a different process in surviving motor neurons. Muscle Nerve 50: 602-604, 2014.
Comparing axonal excitability in past polio to amyotrophic lateral sclerosis
과거 폴리오와 근위축성 측삭경화증의 축삭 흥분성 비교
[Category] 폴리오,
[Article Type] journal-article
[Source] pubmed
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