Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.
【저자키워드】 COVID-19, SARS-CoV-2, review, Biomarkers, epigenomics, miRNAs, 【초록키워드】 immune response, Biomarker, Biomarkers, Diseases, miRNA, database, Replication, miRNAs, Viral, animals, severity of COVID-19, viral replication, Research, Potential biomarker, proliferation, infected cells, potential biomarkers, material, diagnosing, cardiovascular dysfunction, miR-126, miR-155, Cell, independent, selected, described, identify, carried, nine, provide, in viral, suggested, dysregulated, resolved, patients with COVID-19, 【제목키워드】 Biomarker, miRNA, miRNAs, Research, role,