The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
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【저자키워드】 Molecular biology, Molecular medicine, Cancer, Immunopathogenesis, 【초록키워드】 Inflammation, Diseases, knowledge, Transcription, signaling pathway, Autoimmune diseases, inhibitor, expression, Critical, JAK/STAT, Signaling, Evidence, dysregulation, Activation, Regulation, janus, JAK/STAT pathway, cellular processes, highlight, induce, 【제목키워드】 JAK/STAT signaling,
【저자키워드】 Molecular biology, Molecular medicine, Cancer, Immunopathogenesis, 【초록키워드】 Inflammation, Diseases, knowledge, Transcription, signaling pathway, Autoimmune diseases, inhibitor, expression, Critical, JAK/STAT, Signaling, Evidence, dysregulation, Activation, Regulation, janus, JAK/STAT pathway, cellular processes, highlight, induce, 【제목키워드】 JAK/STAT signaling,