Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)—the Pfizer-BioNTech mRNA COVID-19 vaccine—in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-γ/IL-2R/IL-18/IL-16/IL-10) and steroid responsiveness. The close temporal association of vaccination and diagnosis of CRS in this case suggests that CRS was a vaccine-related adverse event; with anti-PD1 blockade as a potential contributor. Overall, further prospective pharmacovigillence data are needed in patients with cancer, but the benefit–risk profile remains strongly in favor of COVID-19 vaccination in this population. A rare case of cytokine release syndrome in a patient on anti-PD-1 blockade that was likely related to BNT162b2 vaccination supports prospective monitoring of patients with cancer after COVID-19 vaccine administration.
【저자키워드】 Cancer immunotherapy, RNA vaccines, Colon cancer, 【초록키워드】 COVID-19, coronavirus disease, COVID-19 vaccine, vaccination, mRNA vaccine, Cancer, inflammatory markers, Diagnosis, mRNA vaccines, Cytokine release syndrome, BNT162b2, Colorectal cancer, COVID-19 vaccination, mRNA, adverse event, Patient, monotherapy, Pfizer-BioNTech, association, CRS, administration, Immune checkpoint inhibitors, anti-PD1, Support, Patients with cancer, syndrome, favor, blockade, occurred, include, reported, raised, elevated, evidenced, cytokine level, 【제목키워드】 vaccination, BNT162b2, Colorectal cancer, Patient, syndrome,