Dynamic modification of microtubule-dependent transport by effector proteins of intracellular Salmonella enterica

Intracellular Salmonella enterica translocate effector proteins that modify microtubule-dependent transport processes of the host cell and modulate the biogenesis of the Salmonella-containing vacuole (SCV). One functional consequence is the induction of tubular aggregates of endosomal membranes, termed Salmonella-induced filaments or SIFs, and further tubular membrane compartments have recently been described. SIFs are unique, highly dynamic compartments that form by modification of vesicular transport on microtubules. The molecular mechanism of the interference of intracellular Salmonella with host cell vesicular transport is still elusive, but recent studies demonstrate the complexity of pathogenic activities and the intricacy of manipulating host cell functions.