The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies. How COVID-19 pathology differs from other drivers of pneumonia is unclear. Here the authors analyze urine from patients with COVID-19 and identify an immunosuppressive protein expression pattern that is distinct from the pattern in healthy individuals or patients with non-COVID-19 pneumonia.
【저자키워드】 viral infection, Infectious diseases, Proteomic analysis, 【초록키워드】 COVID-19, proteomics, immune response, Pathogenesis, Pneumonia, Immunosuppression, Infectious disease, COVID-19 infection, outbreak, Patient, Urine, molecular, resource, change, Quantitative, moderate, early stage, patients, clinical feature, mechanism, immunosuppressive, COVID-19 patient, Non-COVID-19, worldwide pandemic, protein expression, COVID-19 pathology, impairment, healthy donor, identify, affected, activated, occur, in healthy individual, driver, patients with COVID-19, pneumonia case, 【제목키워드】 COVID-19 disease, early stage,