Background Estimating population prevalence and incidence of prior SARS-CoV-2 infection is essential to formulate public health recommendations concerning the COVID-19 pandemic. However, interpreting estimates based on sero-surveillance requires an understanding of the duration of elevated antibodies following SARS-CoV-2 infection, especially in the large number of people with pauci-symptomatic or asymptomatic disease. Methods We examined > 30,000 serology assays for SARS-CoV-2 specific IgG and IgM assays acquired longitudinally in 11,468 adults between April and November 2020 in the COVID-19 Community Research Partnership. Results Among participants with serologic evidence for infection but few or no symptoms or clinical disease, roughly 50% sero-reverted in 30 days of their initial positive test. Sero-reversion occurred more quickly for IgM than IgG and for antibodies targeting nucleocapsid protein compared with spike proteins, but was not associated with age, sex, race/ethnicity, or healthcare worker status. Conclusions The short duration of antibody response suggests that the true population prevalence of prior SARS-CoV-2 infection may be significantly higher than presumed based on earlier sero-surveillance studies. The impact of the large number of minimally symptomatic COVID-19 cases with only a brief antibody response on population immunity remains to be determined. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-021-06517-6.
【저자키워드】 COVID-19, Sero-surveillance, Humoral response, 【초록키워드】 public health, SARS-CoV-2, IgG, IgM, antibody, SARS-COV-2 infection, COVID-19 pandemic, Antibody Response, Infection, Sex, healthcare worker, nucleocapsid protein, symptomatic, age, incidence, population immunity, estimate, Asymptomatic disease, Evidence, Spike proteins, IgG and IgM, no symptoms, no symptom, supplementary material, COVID-19 case, participant, Positive test, short duration, pauci-symptomatic, clinical disease, population prevalence, serology assays, partnership, recommendation, initial, Result, occurred, elevated, significantly higher, concerning, serology assay, 【제목키워드】 SARS-CoV-2, Duration, partnership,