Background The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Methods We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. Results In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 10 9 /L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. Conclusions COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
【저자키워드】 COVID-19, Risk factors, Laboratory tests, Cox proportional hazards model, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Risk factors, Mortality, Clinical characteristics, hospital, risk, oxygen, risk factor, Disease progression, Retrospective study, Cox proportional hazards model, Laboratory results, White blood cell, Wuhan, morbidity, Patient, Older age, Oxygen therapy, age, morbidity and mortality, public health emergency, Admission, Critical, Invasive mechanical ventilation, blood cell, proportional hazards model, 95% CI, independent risk factors, white blood cell count, increased mortality, independent risk factor, high mortality rate, critical COVID-19 patients, Wuhan, China, multivariable, Result, enrolled, performed, evaluate, died, involved, indicated, diagnosed, required, demonstrated, correlated, Cox proportional hazard, patients with COVID-19, 【제목키워드】 Laboratory tests, risk factor, Clinical outcome, Characteristics, Admission, Laboratory test, critical COVID-19 patient,