Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR = 2.84; 95% CI = 2.06, 3.92) and higher odds of death (OR = 1.39; 95% CI = 1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease. Anecdotal reports suggest potential severity and outcome differences between sexes following infection by SARS-CoV-2. Here, the authors perform meta-analyses of more than 3 million cases collected from global public data to demonstrate that male patients with COVID-19 are 3 times more likely to require intensive care, and have ~40% higher death rate.
【저자키워드】 viral infection, Risk factors, Epidemiology, Systems analysis, 【초록키워드】 COVID-19, Treatment, Meta-analysis, SARS-CoV-2, Coronavirus disease 2019, intensive care, severity, Infection, Sex, outcome, coronavirus SARS-CoV-2, male, female, Patient, death, Clinical management, morbidity and mortality, disease, Admission, Intensive, Evidence, death rate, no difference, females, implication, collected, caused, proportion, reported, exhibit, Anecdotal, higher odd, patients with COVID-19, 【제목키워드】 COVID-19, Meta-analysis, Sex, risk factor, death, Admission,