Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with severe COVID-19 infection. Clinical data of severe COVID-19 patients admitted at the Union Hospital, Wuhan between 28th January and 29th February 2020 were collected and analyzed. 10 patients (1.96%) had a medical history of PD with a mean (SD) age of 72.10 (± 11.46) years. The clinical characteristics and outcomes of severe COVID-19 with and without PD patients were then compared. There was no significant difference in overall mortality between the PD and non-PD patients with severe COVID-19 ( p > 0.05). In PD patients with severe COVID-19, the proportion of patients with critical type, disturbance of consciousness, incidence of complications, white blood cells count and neutrophils counts on admission seem higher in the non-survivors. PD patients with older age, longer PD duration, and late stage PD may be highly susceptible to critical COVID-19 infection and bad outcome. The PD patients with consciousness disorders and complications that progressed rapidly are at increased risk of death. Supplementary Information The online version contains supplementary material available at 10.1007/s00702-020-02283-y.
【저자키워드】 COVID-19, SARS-CoV-2, Clinical characteristics, clinical outcomes, Parkinson’s disease, 【초록키워드】 severe COVID-19, Prognosis, neutrophil, outcome, risk factor, outcomes, White blood cell, COVID-19 infection, clinical, Wuhan, Patient, Older age, death, Complication, complications, age, incidence, Admission, Critical, Parkinson’s disease, Severe COVID-19 Infection, Non-survivors, supplementary material, no significant difference, overall mortality, increased risk, late stage, disorder, Union Hospital, susceptible, analyzed, collected, proportion, affecting, disturbance of consciousness, progressed, severe COVID-19 patient, 【제목키워드】 Wuhan, Parkinson’s disease,