Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.
【저자키워드】 Cancer, TMPRSS2, 【초록키워드】 COVID-19, ACE2, Clinical characteristics, SARS-COV-2 infection, lymphopenia, Colorectal cancer, Patient, expression, epithelial, respiratory rate, Support, tissues, hypersensitive C-reactive protein, susceptible, were expressed, COVID-19 in patient, patients with COVID-19, single-cell RNA-seq profile, with COVID-19, 【제목키워드】 COVID-19, ACE2, Clinical characteristics, Colorectal cancer, Patient, expression,