Abstract To investigate the clinical characteristics and outcome of octogenarians with covid-19. This is a observational, retrospective, descriptive study. Consecutive patients aged >80 years who were admitted for covid-19 pneumonia during a 6 weeks period (March 20–April 30, 2020). Illness severity on admission was classified according to World Health Organization (WHO) criteria: mild, moderate, severe, and critical. Data collected included demographics, presenting symptoms, radiological and laboratory findings, comorbidities, functional status, treatment, and clinical outcome. There were 159 patients (52.2% women) with a median age of 85.99 (IQR: 80–98). The median Barthel index was 90 (40–100) and Charlson index was 5 (5–6). Most common presenting symptoms were fever, dyspnea, and cough. Patients had mild (8.2%), moderate (52.2%), or severe (39.6%) illness according to WHO criteria. A bilateral pulmonary involvement was seen in 86% of patients. Laboratory analysis revealed increased serum concentrations of inflammatory parameters (C-reactive protein, ferritin, lactate dehydrogenase, and D-dimer) with an abnormal lymphocyte count [0.88 × 10 9 /L (0.5)]. Treatments included corticosteroids in 37%, and biological therapies in 17.6%. Fifty three (33.3%) patients died during hospitalization, with a median time from admission to death of 3 (IQR 1–6) days. Mortality was higher in men (55%). Deceased patients had a significantly higher frequency of dyspnea, increased inflammatory parameters, and illness severity compared to survivors. One-third of octogenarians with covid-19 died during hospitalization and most had bilateral lung involvement. A further knowledge of the characteristics and outcome of this population may assist clinicians in the decision-making process in these patients.
【저자키워드】 COVID-19, Mortality, elderly, Illness severity, 【초록키워드】 Corticosteroid, Treatment, therapy, Hospitalization, Clinical characteristics, Pneumonia, knowledge, severity, lung involvement, Comorbidities, C-reactive protein, D-dimer, ferritin, outcome, cough, lactate dehydrogenase, Laboratory, Clinical outcome, Lymphocyte count, serum, Characteristics, Survivors, Fever, Dyspnea, Patient, death, Mild, WHO, women, Admission, Critical, moderate, patients, retrospective, Frequency, Concentration, Analysis, inflammatory parameters, demographics, presenting symptoms, presenting symptom, World Health Organization, Charlson index, clinician, median time, median age, pulmonary involvement, MOST, men, radiological, collected, died, median, functional, significantly higher, illness, assist, inflammatory parameter, IQR, patients died, WHO criteria, 【제목키워드】 outcome, Characteristics, clinical, Patient,