Background and Objectives : Preventive, adjunctive and curative properties of lactoferrin have been evaluated since the first wave of severe acute respiratory syndrome coronavirus (SARS-CoV), a viral respiratory disease, emerged 18 years ago. Despite the discovery of new vaccine candidates, there is currently no widely approved treatment for SARS-CoV-2 (COVID-19). Strict adherence to infection prevention and control procedures, as well as vaccines, can, however, prevent the spread of SARS-CoV-2. This study aimed to evaluate the efficacy of lactoferrin treatment in improving clinical symptoms and laboratory indices among individuals with mild to moderate coronavirus disease-19 (COVID-19). Materials and Method : A randomized, prospective, interventional pilot study conducted between 8 July and 18 September 2020 used a hospital-based sample of 54 laboratory-confirmed participants with mild to moderate symptoms of COVID-19. Randomization into a control and two treatment groups ensured all groups received the approved Egyptian COVID-19 management protocol; only treatment group participants received lactoferrin at different doses for seven days. Clinical symptoms and laboratory indices were assessed on Days 0, 2 and 7 after starting treatments. Mean values with standard deviation and one-way analysis of variance with least significant difference of demographic and laboratory data between control and treatment groups were calculated. Results : Our study showed no statistically significant difference among studied groups regarding recovery of symptoms or laboratory improvement. Conclusions : Further research into therapeutic properties particularly related to dosage, duration and follow-up after treatment with lactoferrin in individuals with COVID-19 is required.
【저자키워드】 COVID-19, SARS-CoV-2, lactoferrin, adjunctive, Egyptian COVID-19 management protocol, 【초록키워드】 Treatment, Efficacy, coronavirus, Vaccines, SARS-CoV, Symptom, Laboratory, Spread, Randomized, Coronavirus disease-19, clinical, management, therapeutic, Research, Infection prevention, Mild, Follow-up, group, disease, First wave, moderate, analysis of variance, Standard deviation, acute respiratory syndrome, significant difference, pilot study, dosage, clinical symptom, individual, laboratory data, statistically significant difference, treatment group, participant, vaccine candidates, material, symptoms of COVID-19, laboratory-confirmed, objective, Prevent, Seven, Result, evaluate, evaluated, Day, required, approved, conducted, calculated, viral respiratory, curative, different dose, individuals with COVID-19, were assessed, 【제목키워드】 agent,