Background and Objectives: The aim of this study was to investigate the association between obesity and 28-day mortality, duration of invasive mechanical ventilation and length of stay at the Intensive Care Unit (ICU) and hospital in patients admitted to the ICU for SARS-CoV-2 pneumonia. Materials and Methods: This was a retrospective observational cohort study in patients admitted to the ICU for SARS-CoV-2 pneumonia, in a single Dutch center. The association between obesity (body mass index > 30 kg/m 2 ) and 28-day mortality, duration of invasive mechanical ventilation and length of ICU and hospital stay was investigated. Results: In 121 critically ill patients, pneumonia due to SARS-CoV-2 was confirmed by RT-PCR. Forty-eight patients had obesity (33.5%). The 28-day all-cause mortality was 28.1%. Patients with obesity had no significant difference in 28-day survival in Kaplan–Meier curves (log rank p 0.545) compared with patients without obesity. Obesity made no significant contribution in a multivariate Cox regression model for prediction of 28-day mortality ( p = 0.124), but age and the Sequential Organ Failure Assessment (SOFA) score were significant independent factors ( p < 0.001 and 0.002, respectively). No statistically significant correlation was observed between obesity and duration of invasive mechanical ventilation and length of ICU and hospital stay. Conclusion: One-third of the patients admitted to the ICU for SARS-CoV-2 pneumonia had obesity. The present study showed no relationship between obesity and 28-day mortality, duration of invasive mechanical ventilation, ICU and hospital length of stay. Further studies are needed to substantiate these findings.
【저자키워드】 SARS-CoV-2, obesity, intensive care unit, severe acute respiratory syndrome coronavirus-2, Invasive mechanical ventilation, Length of stay, 【초록키워드】 Pneumonia, hospital, 28-day mortality, RT-PCR, ICU, body mass index, survival, Patient, age, SOFA, SARS-CoV-2 pneumonia, correlation, assessment, critically ill patients, association, retrospective, Hospital stay, Observational cohort study, Factor, significant difference, failure, all-cause mortality, multivariate Cox regression, log rank, material, Kaplan–Meier, independent, the patient, investigated, had no, statistically significant, 【제목키워드】 Duration, respiratory, Length, Ill, Mechanical,