Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 (coronavirus disease 2019), which is associated with high morbidity and mortality, especially in elder patients. Acute respiratory distress syndrome (ARDS) is a life-threatening complication of COVID-19 and has been linked with severe hyperinflammation. Dexamethasone has emerged as standard of care for COVID-19 associated respiratory failure. In a non-randomized prospective phase II multi-center study, we asked whether targeted inhibition of Janus kinase-mediated cytokine signaling using ruxolitinib is feasible and efficacious in SARS-CoV-2- induced ARDS with hyperinflammation. Sixteen SARS-CoV-2 infected patients requiring invasive mechanical ventilation for ARDS were treated with ruxolitinib in addition to standard treatment. Ruxolitinib treatment was well tolerated and 13 patients survived at least the first 28 days on treatment, which was the primary endpoint of the trial. Immediate start of ruxolitinib after deterioration was associated with improved outcome, as was a lymphocyte-to-neutrophils ratio above 0.07. Together, treatment with the janus-kinase inhibitor ruxolitinib is feasible and might be efficacious in COVID-19 induced ARDS patients requiring invasive mechanical ventilation. The trial has been registered under EudraCT-No.: 2020-001732-10 and NCT04359290.
【저자키워드】 Infectious diseases, Phase II trials, 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, ARDS, coronavirus, Respiratory failure, Trial, outcome, Deterioration, hyperinflammation, Patient, ruxolitinib, morbidity and mortality, inhibitor, cytokine signaling, Invasive mechanical ventilation, distress, Standard of care, acute respiratory syndrome, standard treatment, janus, syndrome, life-threatening, Registered, complication of COVID-19, addition, treated, non-randomized, cause, feasible, survived, ARDS patient, asked, elder patients, Immediate, SARS-CoV-2 infected patient, the primary endpoint, 【제목키워드】 SARS-CoV-2, ARDS, ruxolitinib, inhibitor, acute respiratory distress, syndrome,