Background Seroprevalence of anti-SARS-CoV-2 antibodies is now available in several world regions to better estimate transmission dynamics. However, to date, there is no epidemiological data regarding anti-SARS-CoV-2 prevalence in Mexico. Therefore, we aimed to determine the prevalence of anti-SARS-CoV-2 antibodies and define the clinical and demographic characteristics associated with seroprevalence. Methods We conducted a cross-sectional serological survey in Ciudad Guadalupe, NL, Mexico. City government employees voluntarily participated during July 2020. Demographic and clinical characteristics were collected at the time of blood sampling to analyze the associated characteristics. IgM/IgG antibodies were determined using a qualitative chemiluminescent immunoassay. Descriptive statistics were used for categorical and continuous variables. Statistical significance was tested using the Chi-squared test, Student’s t-test and the Mann–Whitney. Logistic regression models and the odds ratios (adjusted and unadjusted) were used to estimate the association of demographic and clinical characteristics. Results Of the 3,268 participants included, 193 (5.9%, 95% CI 5.1–6.8) tested positive for IgM/IgG against SARS-CoV-2. Sex, city of residence, and comorbidities did not show any association with having IgM/IgG antibodies. A total of 114 out of 193 (59.1%) subjects with a positive test were asymptomatic, and the odds of being positive were higher in those who reported symptoms of COVID-19 in the previous four weeks to the survey (OR 4.1, 95% CI 2.9–5.5). Conclusions There is a low rate of SARS-CoV-2 infection among government employees that have continuously been working during the pandemic. Six in ten infections were asymptomatic, and seroprevalence is low and still far from herd immunity. Epidemiological surveillance and preventive measures should be mandatory.
【저자키워드】 COVID-19, serology, survey, anti-SARS-CoV-2, Prevalence, Mexico, 【초록키워드】 antibodies, SARS-CoV-2, pandemic, Immunity, Clinical characteristics, antibody, cross-sectional, SARS-COV-2 infection, Seroprevalence, Infection, Comorbidities, Comorbidity, anti-SARS-CoV-2, anti-SARS-CoV-2 antibodies, Region, Characteristics, Asymptomatic, anti-SARS-CoV-2 antibody, IgG antibodies, IgM/IgG, herd immunity, Regression model, Transmission dynamics, epidemiological data, preventive measures, epidemiological surveillance, chemiluminescent immunoassay, demographic, Blood, association, Odds ratio, demographic characteristics, preventive measure, Government, 95% CI, subject, city, statistical significance, Odds ratios, Descriptive statistics, participant, Positive test, residence, demographic and clinical characteristics, symptoms of COVID-19, logistic regression models, blood sampling, positive, Chi-squared test, serological survey, Student’s t-test, Result, tested, collected, conducted, adjusted, were used, determine, mandatory, participated, reported symptom, variables, was tested, 【제목키워드】 pandemic, Characteristics, anti-SARS-CoV-2 antibody,