Background: Little is known on the clinical relevance of the nutritional status and body composition of patients hospitalized with SARS-CoV-2 infection. The aim of our study was to assess the prevalence of malnutrition in patients with COVID-19 pneumonia using bioelectrical impedance vector analysis (BIVA), and to evaluate the relationship of their nutritional status with the severity and outcome of disease. Methods: Among 150 consecutive patients who were hospitalized with COVID-19 pneumonia, 37 (24.3%) were classified as malnourished by BIVA, and were followed-up for 60 days from admission. Outcome measures were differences in the need for invasive mechanical ventilation, in-hospital mortality, and the duration of hospital stay in survivors. Results: During 60 days of follow-up, 10 (27%) malnourished patients and 13 (12%) non-malnourished patients required invasive mechanical ventilation ( p = 0.023), and 13 (35%) malnourished patients and 9 (8%) non-malnourished patients died ( p < 0.001). The average duration of the hospital stay in survivors was longer in patients with malnutrition (18.2 ± 15.7 vs. 13.2 ± 14.8 days, p < 0.001). In survival analyses, mechanical ventilation free (log-rank 7.887, p = 0.050) and overall (log-rank 17.886, p < 0.001) survival were significantly longer in non-malnourished than malnourished patients. The Cox proportional ratio showed that malnutrition was associated with an increased risk of mechanical ventilation (HR 4.375, p = 0.004) and death (HR 4.478, p = 0.004) after adjusting for major confounders such as age, sex, and BMI. Conclusions: Malnutrition diagnosed with BIVA was associated with worse outcomes in hospitalized patients with COVID-19 pneumonia.
【저자키워드】 COVID-19, Malnutrition, BIVA, bioelectrical impedance vector analysis, low cellular mass, 【초록키워드】 Hospitalized, mechanical ventilation, Pneumonia, SARS-COV-2 infection, severity, Sex, outcome, Prevalence, survival, Survivors, Patient, death, age, Follow-up, body composition, BMI, disease, Admission, patients, in-hospital mortality, Invasive mechanical ventilation, Analysis, nutritional status, Hospital stay, increased risk, average, measure, survivor, confounder, evaluate, significantly, diagnosed, required, hospitalized patient, analyses, consecutive patient, patients died, patients hospitalized, patients with COVID-19, with COVID-19, 【제목키워드】 vector, Prospective, impedance, role, with COVID-19,