Aims/hypothesis The strict rules applied in Italy during the recent COVID-19 pandemic, with the prohibition to attend any regular outdoor activity, are likely to influence the degree of metabolic control in patients with type 2 diabetes. We explored such putative effect immediately after the resolution of lockdown rules, in the absence of any variation of pharmacologic treatment. Methods One-hundred and fourteen patients with adequate metabolic control took part in this single-centre, prospective, observational study. The metabolic profile tested 1 week after the end of the lockdown was compared with the last value and the mean of the last three determinations performed before the pandemic emergency (from 6 months to 2 years before). Results After 8 weeks of lockdown, an increase of HbA1c > 0.3% (mean +0.7%) was observed in 26% of the participants; these were also characterized by a persistent elevation in serum triglycerides able to predict the worsening of glucose control. Conclusions Lockdown determined a relevant short-term metabolic worsening in approximately one-fourth of previously well-controlled type 2 diabetic individuals; pre-lockdown triglycerides were the only parameter able to predict such derangement of glucose control. Electronic supplementary material The online version of this article (10.1007/s00592-020-01637-y) contains supplementary material, which is available to authorized users.
【저자키워드】 Physical inactivity, type 2 diabetes, COVID-19 lockdown, Metabolic control, 【초록키워드】 pandemic, lockdown, COVID-19 pandemic, Variation, diabetes, Italy, observational study, type 2 diabetes, serum, Patient, Triglyceride, predict, Glucose, triglycerides, glucose control, Diabetic, pharmacologic treatment, supplementary material, worsening, prohibition, parameter, Result, tested, performed, applied, characterized, absence, the mean, 【제목키워드】 COVID-19, Patient,