The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin–angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed.
All Keywords
【저자키워드】 RAGE, COVID-19 comorbidities,AGER polymorphisms, 【초록키워드】 SARS-CoV-2, Inflammation, severe COVID-19, RAGE, Infection, polymorphism, Comorbidity, oxidative stress, RAS, therapeutic, Patient, receptor, Pathologies, COVID-19 patients, Ligand, angiotensin, Inflammatory, renin–angiotensin system, molecular target, deleterious effects, Hyperactivation, multiligand receptor, multiorgan injury, reported, appear, deleterious effect, 【제목키워드】 Crosstalk, Factor, role,
【저자키워드】 RAGE, COVID-19 comorbidities,
RAGE(Advanced glycation-end product) 수용체는 염증 및 폐 병리에서 역할을 하는 다중 리간드 수용체입니다. 리간드에 의한 RAGE의 과활성화는 심각한 COVID-19의 일반적인 동반 질환에서 염증 및 산화 스트레스를 유지하는 것으로 보고되었습니다. RAGE는 COVID-19 환자의 감염 및 다기관 손상에 참여하는 레닌-안지오텐신 시스템(RAS)의 해로운 영향에 필수적입니다. 따라서 RAGE는 심각한 COVID-19의 주요 역할을 할 수 있으며 SARS-CoV-2 감염에 유용한 치료 분자 표적인 것으로 보입니다. 심각한 COVID-19에 환자를 소인시키는 RAGE 유전자 다형성의 역할에 대해 논의합니다.