SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Neutrophil extracellular traps, immunothrombosis, CID, 【초록키워드】 Neutrophils, infection control, coronavirus, Mortality, innate immune response, severe COVID-19, COVID-19 pandemic, neutrophil, CRP, D-dimer, MPO, hospitalized patients, lactate dehydrogenase, respiratory diseases, Coagulation, clinical manifestations, DNA, family, interleukin, Viral, outbreak, Respiratory disease, Kidney disease, respiratory, Thrombotic events, NETs, mechanism, fungal, Bacterial, acute phase reactants, marker, Disseminated intravascular coagulation, Lactate, Inflammatory mediators, Interaction, severe disease, leads, causative agent, clinical manifestation, acute phase reactant, Activation, Recognition, Vascular, Previous studies, increased risk, thrombotic, member, previous study, intravascular coagulation, total neutrophil count, activation pathway, NET, Cell, thrombotic event, Extracellular, shown, analyzed, include, involved, elevated, hospitalized patient, etiological, patients with COVID-19, recruit, with COVID-19,