Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1ß production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.
【저자키워드】 viral infection, Inflammasome, 【초록키워드】 COVID-19, Monocytes, SARS-CoV-2, coronavirus, therapy, intensive care, severe COVID-19, monocyte, Peripheral blood, Patient, pyroptosis, death, 2019 coronavirus disease, cleavage, hyper-inflammation, respiratory tract, caspase-1, mechanism, critically ill patients, Inflammatory response, Trigger, gasdermin D, acute respiratory syndrome, Activation, leukopenia, pro-inflammatory cytokine, IL-1ß, human monocytes, cellular component, recruited, engage, reduce viral replication, 【제목키워드】 SARS-CoV-2, monocyte, pyroptosis, engage,