Objective The use of remdesivir for pregnant patients with coronavirus disease 2019 (COVID-19) showed conflicting results in prior studies. We aimed to systematically review its efficacy and safety for this population from the existing literature. Methods On July 26, 2021, registries ( ClinicalTrials.gov ) and databases (MEDLINE, ScienceDirect, Cochrane Library, JSTOR, DOAJ, and medRxiv) were systematically searched for research articles investigating remdesivir use in pregnant people with COVID-19. Clinical outcome, hospitalization duration, laboratory outcome, mortality, and adverse events were investigated. Results We obtained 13 observation studies with 113 pregnant people. In these studies, remdesivir improved the clinical condition of pregnant patients with COVID-19, especially those who had a better clinical status at baseline and received earlier remdesivir treatment. Most fetuses were delivered via cesarean section, primarily because of emergency causes. No vertical transmissions were noted. The most reported adverse event was transaminitis, in which 10-day remdesivir treatment yielded more incidence than the 5-day treatment. Conclusions In pregnancy, the use of Remdesivir in combination with other COVID-19 treatments is inconclusive but its use should be followed with careful monitoring of adverse reactions and transaminase enzyme levels. Further studies are required to confirm its finding. COVID-19; SARS-CoV-2; Pregnancy; Remdesivir; Antiviral therapy.
【저자키워드】 COVID-19, SARS-CoV-2, antiviral therapy, Remdesivir, Pregnancy, 【초록키워드】 Treatment, coronavirus disease, therapy, Mortality, Hospitalization, Transmission, outcome, database, Laboratory, clinical status, COVID-19 treatment, clinical, adverse event, Research, Efficacy and safety, incidence, Combination, pregnant, Adverse reaction, observation, enzyme, causes, Cochrane Library, transaminitis, article, clinical condition, MOST, Inconclusive, objective, Result, reported, investigated, required, searched, baseline, JSTOR, people with COVID-19, pregnant patient, with COVID-19, 【제목키워드】 systematic review,