Disturbance of cardiovascular circadian rhythms by pertussis vaccine in freely-moving rats

자유롭게 움직이는 쥐에서 백일해 백신에 의한 심혈관 생체리듬의 방해

Published on
Journal: Health and Technology
[저자] W. Vleeming, A. van de Kuil, J. D. te Biesebeek, J. W. van der Laan, D. J. de Wildt, J. G. C. van Amsterdam
[Category] 백일해, 파상풍,
Pubmed URL    DOI URL    [DOI] 10.1258/002367700780387697    
[Article Type] journal-article
[Source] pubmed

Vaccination of young children with diphtheria, tetanus, poliomyelitis and pertussis (DTPoP) vaccine is effective in preventing outbreaks of whooping cough but adverse events sometimes occur. This pilot study shows that in freely-moving rats, multiple treatment with DTPoP (at day 0 and day 5, 6 ml/kg i.v.) increased heart rate (HR) for 5 days after the first treatment and decreased diastolic blood pressure (DBP) for at least 26 days after the first treatment and inhibited the circadian rhythm of HR and DBP for at least 10 days. DTPo vaccine, containing no pertussis vaccine, was free of such effects. Thus, in rats, the pertussis component of DTPoP acts on the cardiovascular system and disturbs its circadian rhythm. The contribution of these findings to clinical adverse effects is as yet unknown and needs further research.

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