There will be an increasing demand for safe and effective combination vaccines as more paediatric vaccines are developed and licensed for new indications. The successful introduction of new combination vaccines into the childhood immunization schedule has the potential to improve vaccine coverage and thus reduce morbidity and mortality from childhood infections, and also possibly to reduce the cost of vaccines and their delivery. This article reviews the recent literature regarding new combination vaccines and discusses the main issues surrounding the simultaneous administration of multiple vaccine antigens to children.
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